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KMID : 1020120070050010045
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Journal of the Korean Academy of Clinical Electrophysiology
2007 Volume.5 No. 1 p.45 ~ p.58
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Effects on Nociceptive Neuron Excitability by application of Electroacupuncture and Meloxicam gel in Rat with Inflammation
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Kim Young-Phil
Lee Jeong-Woo
Seo Sam-Ki
Yoon Se-Won
Yoon Hee-Jong
Kim Tae-Youl
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Abstract
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This study aims to examine the effects on nociceptive neuron excitability by application of electroacupuncture and Meloxicam gel in rat with inflammation. It used 24 rats for experiment, divided them into control group, electroacupuncture group(EA group), Meloxicam group(ME group), combination of electroacupuncture with Meloxicam group(EA+ME group), caused hyperalgesia by injecting -carrageenan into hindpaw and conducted treatment three times for experimental period. Noxious flexion withdrawal reflex(NFR) and somatosensory evoked potential(SEP) were measured immediately after induction, at 24 hours, 48 hours and 72 hours after induction. Change of NFR(reaction time, RMS) showed no significant differences among EA group, Meloxicam group, and EA+Meloxicam group, but all treatment groups showed significant differences compared to control group from 48 hours. In NFR threshold, there were significant differences between EA+Meloxicam and other groups. In SEP amplitude, there were significant differences between EA+Meloxicam and control group from 48 hours. This study showed that EA+Meloxicam gel had an effect on nociceptive neurone excitability. Therefore, it is considered that appropriate combination of anti-inflammatory drug with electroacupuncture for pain control will be very desirable.
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KEYWORD
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Meloxicam, NFR, SEP, Electroacupuncture
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